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Longevity Drugs & Compounds Dataset – Anti-Aging & Life Extension Substances
Longevity Drugs & Compounds Dataset
The Longevity Drugs & Compounds Dataset is a curated database of substances that have been studied for their potential role in extending lifespan, improving cellular health, and slowing biological aging.
The dataset includes pharmaceuticals, natural compounds, and dietary supplements that have been investigated in longevity and aging research. These compounds may influence biological pathways such as cellular repair, metabolism, inflammation, oxidative stress, and mitochondrial function.
This dataset is useful for biotech researchers, longevity scientists, healthcare developers, and data scientists who need structured data for studying anti-aging compounds, developing health applications, or building AI models focused on longevity research.
All records have been cleaned and organised for easy use in spreadsheets, databases, and analytical tools.
Dataset Contents
The dataset includes fields such as:
- Compound / Drug Name
- Compound Type (Drug, Supplement, Natural Compound)
- Primary Longevity Mechanism
- Biological Pathway Affected
- Research Status (Experimental / Clinical Research / Approved Use)
- Potential Benefits
- Notes / Additional Information
Example Compounds Included
- Metformin
- Rapamycin
- Resveratrol
- Nicotinamide Riboside (NR)
- Nicotinamide Mononucleotide (NMN)
- Spermidine
- Fisetin
- Quercetin
- Curcumin
- Berberine
...and other compounds studied in longevity science.
Data Preview
10 columns
25 rows shown
| # | Compound | Category | Class | Primary Medical Use | Proposed Longevity Mechanism | Evidence Level | Model Organism Data | Human Data | Key Notes | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | Rapamycin (Sirolimus) | mTOR / Growth Signalling | mTOR inhibitor | Immunosuppressant (organ transplant) | Inhibits mTORC1; promotes autophagy and cellular recycling; reduces senescence | Strong | Extended lifespan in mice up to 26% (ITP); also in yeast, worms, flies | Trials on immune ageing (PEARL); topical skin ageing trials show benefit | Most robust mammalian lifespan extension; ITP-validated; dosing schedule under study |
| 2 | 2 | Acarbose | Metabolic / Glucose | Alpha-glucosidase inhibitor | Type 2 diabetes | Reduces post-meal glucose spikes; mimics caloric restriction signalling | Strong | Extended lifespan in male mice ~22%; modest in females (ITP) | Long safety record in diabetes patients | ITP-validated; greater effect in males; well-tolerated; inexpensive |
| 3 | 3 | Metformin | Metabolic / Glucose | Biguanide | Type 2 diabetes | Activates AMPK; reduces inflammation, oxidative stress, and IGF-1 signalling | Moderate–Strong | Mixed results in mice; some lifespan extension at lower doses | Epidemiological: diabetics on metformin outlived non-diabetic controls; TAME trial ongoing | TAME trial is the first FDA-approved ageing trial; widely used; very inexpensive |
| 4 | 4 | Anti-IL-11 (X203) | Anti-inflammatory | Anti-inflammatory antibody | Experimental | Blocks IL-11 pro-ageing signalling; reduces fibrosis, inflammation, and metabolic decline | Emerging | Extended lifespan ~25% in mice (Nature, 2024) | Not yet in human ageing trials | Novel target; published in Nature 2024; potential first-in-class geroprotector |
| 5 | 5 | Trametinib | mTOR / Growth Signalling | MEK inhibitor | Cancer (melanoma) | Inhibits RAS-MAPK pathway; reduces cellular senescence and growth signalling | Moderate | Extended lifespan in Drosophila ~12%; limited mammalian ageing data | FDA-approved for cancer; no human ageing trials | Repurposing for ageing is early-stage; significant side-effect profile |
| 6 | 6 | 17α-Estradiol | Hormonal | Non-feminising estrogen | Experimental | Reduces chronic inflammation; modulates hypothalamic and metabolic pathways | Strong | Extended lifespan in male mice 12–19% (ITP); no effect in females | No human ageing trials | ITP-validated; does not feminise males; mechanism not fully understood |
| 7 | 7 | Resveratrol | Antioxidant / Polyphenol | Polyphenol (SIRT1 activator) | Supplement | Activates sirtuins (SIRT1); antioxidant and anti-inflammatory effects | Weak–Moderate | Extended lifespan in some invertebrates; inconsistent in mice; benefits on high-fat diet | Small human trials show improved vascular function; no mortality data | Found in red wine/grapes; poor bioavailability; overshadowed by more potent analogues |
| 8 | 8 | Curcumin | Antioxidant / Polyphenol | Polyphenol | Supplement / traditional medicine | Anti-inflammatory (NF-κB inhibition); antioxidant; may reduce senescent cell burden | Weak–Moderate | Some lifespan extension in flies and worms; limited mammalian data | Anti-inflammatory benefits in small human trials; no mortality data | Very poor bioavailability; enhanced forms (e.g. with piperine) improve absorption |
| 9 | 9 | N-Acetyl Cysteine (NAC) | Antioxidant / Polyphenol | Antioxidant / mucolytic | Mucolytic; acetaminophen overdose | Glutathione precursor; reduces oxidative stress and supports detoxification | Weak–Moderate | Some lifespan extension in flies and worms; mixed results in mice | Long safety record; no human ageing-specific trials | Widely available OTC supplement; generally well-tolerated |
| 10 | 10 | Ivermectin | Antiparasitic / Antibiotic | Antiparasitic (avermectin) | Parasitic infections | DAF-16/FOXO pathway activation; anti-inflammatory properties | Weak | Extended lifespan in C. elegans; very limited mammalian ageing data | Nobel Prize-winning antiparasitic; no human ageing data | Longevity research is preliminary; primarily a veterinary/human antiparasitic |
| 11 | 11 | Erythromycin | Antiparasitic / Antibiotic | Macrolide antibiotic | Bacterial infections | May modulate gut microbiome; mild mTOR modulation suggested | Weak | Limited data; some invertebrate studies | No human ageing data | Longevity link is speculative; risk of antibiotic resistance with chronic use |
| 12 | 12 | Capecitabine | Chemotherapy | Antimetabolite (fluoropyrimidine) | Cancer (breast, colorectal) | Senolytic-adjacent effects; targets rapidly dividing / senescent cells | Weak | Limited direct longevity data; anti-cancer mechanism may clear senescent cells | Approved cancer drug; no ageing trials | Significant side effects limit repurposing potential for healthy ageing |
| 13 | 13 | Pravastatin | Cardiovascular | Statin (HMG-CoA reductase inhibitor) | High cholesterol; cardiovascular disease | Reduces inflammation and cholesterol; pleiotropic anti-ageing effects | Moderate | Some lifespan data in Drosophila; cardiovascular benefits in mammals | Strong human CV mortality reduction data; epidemiological longevity association | Well-established safety profile; longevity benefit likely secondary to CV protection |
| 14 | 14 | Rilmenidine | Autophagy Inducer | Imidazoline receptor agonist | Hypertension | Induces autophagy independently of mTOR; reduces ageing biomarkers | Emerging | Extended lifespan in C. elegans ~19% (Nature Aging, 2023) | Approved antihypertensive; no human ageing trials yet | Oral bioavailability; mTOR-independent autophagy is a unique mechanism |
| 15 | 15 | Dasatinib + Quercetin (D+Q) | Senolytic | Senolytic combination (TKI + flavonoid) | Dasatinib: cancer; Quercetin: supplement | Selectively clears senescent cells; reduces SASP inflammatory burden | Strong | Improved healthspan and lifespan in aged mice; reduced senescent cell burden | Phase I/II trials in idiopathic pulmonary fibrosis and diabetic kidney disease show senescent cell clearance | Leading senolytic cocktail; intermittent dosing (hit-and-run); Mayo Clinic pioneered |
| 16 | 16 | Fisetin | Senolytic | Flavonoid / senolytic | Supplement | Clears senescent cells; antioxidant; anti-inflammatory | Moderate | Extended lifespan in aged mice ~10%; reduced senescent markers | AFFIRM trial (Mayo Clinic) ongoing for age-related frailty | Found in strawberries; better bioavailability than quercetin alone; OTC available |
| 17 | 17 | Nicotinamide Mononucleotide (NMN) | NAD+ / Mitochondrial | NAD+ precursor | Supplement | Replenishes NAD+ levels; supports sirtuin activity and mitochondrial function | Moderate | Improved metabolic health, exercise capacity, and vascular function in aged mice | Small human trials show improved muscle insulin sensitivity and NAD+ levels | Widely sold as supplement; FDA briefly classified it as investigational drug in US |
| 18 | 18 | Nicotinamide Riboside (NR) | NAD+ / Mitochondrial | NAD+ precursor (vitamin B3 form) | Supplement | Raises NAD+ levels; supports mitochondrial function and DNA repair | Moderate | Improved healthspan markers in mice; limited direct lifespan data | Human trials confirm NAD+ elevation; cardiovascular and cognitive trials ongoing | Commercially available (Tru Niagen); better studied pharmacokinetically than NMN |
| 19 | 19 | Spermidine | Autophagy Inducer | Natural polyamine | Supplement / dietary compound | Potent autophagy inducer; promotes cellular recycling and cardioprotection | Moderate–Strong | Extended lifespan in yeast, flies, worms, and mice; improved cardiac function | Epidemiological: high dietary spermidine intake associated with reduced mortality (Bruneck Study) | Found in wheat germ, aged cheese, mushrooms; one of few dietary compounds with strong autophagy data |
| 20 | 20 | Taurine | Amino Acid / Nutrient | Semi-essential amino acid | Supplement / energy drinks | Levels decline with age; supplementation reduces senescence, inflammation, and DNA damage | Moderate–Strong | Extended lifespan in mice ~10-12%; improved healthspan across multiple organs (Science, 2023) | Blood taurine levels inversely correlate with ageing markers in humans; trials planned | Published in Science (June 2023); abundant in meat and fish; inexpensive supplement |
| 21 | 21 | Glycine | Amino Acid / Nutrient | Non-essential amino acid | Supplement / dietary compound | Mimics methionine restriction; supports glutathione synthesis; anti-inflammatory | Moderate | Extended lifespan in rats and mice on methionine-supplemented diets; ITP currently testing | No human ageing trials; long safety record as supplement | Inexpensive; often combined with NAC (GlyNAC protocol); methionine restriction mimetic |
| 22 | 22 | Alpha-Ketoglutarate (AKG) | Metabolic / Glucose | Metabolic intermediate (TCA cycle) | Supplement | Key TCA cycle metabolite; levels decline with age; modulates epigenetic marks (TET enzymes) | Moderate | Extended lifespan in C. elegans ~50%; compressed morbidity in mice (reduced frailty) | Small human trial (Rejuvant) showed ~8-year reduction in biological age (epigenetic clock) | Commercially available as CaAKG supplement; well-tolerated; epigenetic mechanism is novel |
| 23 | 23 | Canagliflozin | Metabolic / Glucose | SGLT2 inhibitor | Type 2 diabetes; heart failure | Reduces glucose reabsorption; caloric restriction mimetic; reduces inflammation | Moderate | Extended lifespan in male mice (ITP, 2019); genetically heterogeneous mice | FDA-approved; strong CV and renal outcome data in diabetics; no dedicated ageing trial | ITP-validated; sex-specific (males only in mice); already widely prescribed |
| 24 | 24 | Lithium (low-dose) | Other | Mood stabiliser / trace element | Bipolar disorder | GSK-3 inhibition; promotes autophagy; neuroprotective; telomere maintenance | Moderate | Extended lifespan in C. elegans and Drosophila at low doses | Epidemiological: trace lithium in drinking water correlates with reduced mortality in multiple studies | Microdosing (e.g. 1 mg) studied; distinct from psychiatric doses (300–1200 mg); low cost |
| 25 | 25 | Berberine | Metabolic / Glucose | Plant alkaloid (isoquinoline) | Traditional medicine; supplement | AMPK activator (similar to metformin); improves insulin sensitivity; anti-inflammatory | Moderate | Extended lifespan in Drosophila; improved metabolic markers in rodents | Lowers blood glucose and LDL cholesterol in human RCTs; often called 'nature's metformin' | Found in goldenseal, barberry; may interact with many medications (CYP inhibitor) |
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