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Zoonotic Diseases
A reference to diseases transmitted between animals and humans, covering causative agents, exposure routes, symptoms, diagnosis, treatment and health impacts.
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A reference to diseases transmitted between animals and humans, covering causative agents, exposure routes, symptoms, diagnosis, treatment and health impacts.
110records
17columns
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Columns
| # | TextID | TextDisease Name | TextCategory | TextPrevalence | TextInheritance Pattern | TextAffected Gene(s) | LocationChromosome Location | TextKey Symptoms | TextTypical Age of Onset | TextDiagnosis Methods | TextAvailable Treatments | TextOrphan Drug Designation | TextICD-10 Code | NumberOMIM Number | TextAffected System | TextDisease Severity | TextLife Expectancy Impact |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 01 | 1 | Rabies (Classical, Dog-mediated) | Viral Zoonosis | ~59,000 human deaths/yr globally (mostly Asia/Africa) | Acquired (Lyssavirus - bite/scratch from infected mammal, mainly dogs) | N/A | N/A | Prodrome (fever, paresthesia at bite), encephalitic (hydrophobia, aerophobia, agitation) or paralytic form, near-100% fatal once symptomatic | All ages | Clinical + exposure history; antemortem RT-PCR (saliva, skin biopsy nape), Negri bodies postmortem, RFFIT serology | US CDC PEP: wound cleansing; previously unvaccinated patients receive HRIG plus IM vaccine on days 0, 3, 7 and 14 (add day 28 and assess antibody response if immunocompromised). Previously vaccinated patients receive vaccine on days 0 and 3, without HRIG. PEP prevents disease before symptoms; established rabies requires specialist supportive care. | No | A82.9 | N/A | Central nervous system | Severe | Reduced (>99% fatal once symptomatic) |
| 02 | 2 | Rabies (Sylvatic - Bat/Wildlife) | Viral Zoonosis | Most US cases bat-related; raccoon, fox, skunk in wildlife | Acquired (bat lyssavirus, raccoon variant - bite, scratch, mucosal contact) | N/A | N/A | Same as classical rabies; bat exposures may go unrecognized | All ages | Exposure history (bat in room), RT-PCR, IFA on brain biopsy | PEP for any unprovoked wildlife bite, all bat exposures, vaccine + RIG | No | A82.0 | N/A | Central nervous system | Severe | Reduced |
| 03 | 3 | Australian Bat Lyssavirus (ABLV) | Viral Zoonosis | Rare; Australia (flying foxes, microbats) | Acquired (ABLV - bat bite/scratch) | N/A | N/A | Rabies-like encephalitis, uniformly fatal; only 3 reported human cases | All ages | RT-PCR, IFA, serology | Standard rabies PEP (vaccine + HRIG), supportive ICU | No | A82.0 | N/A | Central nervous system | Severe | Reduced (fatal) |
| 04 | 4 | European Bat Lyssavirus (EBLV-1/2) | Viral Zoonosis | Rare; Europe (Serotine and Daubenton's bats) | Acquired (EBLV - bat bite) | N/A | N/A | Rabies-like encephalitis, fatal | All ages | RT-PCR, IFA | Rabies PEP (cross-protective vaccine), supportive | No | A82.0 | N/A | Central nervous system | Severe | Reduced |
| 05 | 5 | Nipah Virus Encephalitis | Viral Zoonosis | Outbreaks in Bangladesh, India, Malaysia (~40-75% case fatality) | Acquired (Pteropus fruit bats - contaminated date palm sap, intermediate pigs, person-to-person) | N/A | N/A | Fever, headache, encephalitis, seizures, coma, ARDS; high mortality | All ages | RT-PCR (CSF, throat), IgM/IgG ELISA, virus isolation BSL-4 | Supportive ICU; ribavirin and monoclonal antibody (m102.4) experimental; isolation precautions | No | B33.8 | N/A | Central nervous system/Respiratory | Severe | Reduced |
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