Sample rows from Pediatric Disorders. Field types are labelled in each column heading.
#	TextID	TextDisease Name	TextCategory	TextPrevalence	TextInheritance Pattern	TextAffected Gene(s)	LocationChromosome Location	TextKey Symptoms	TextTypical Age of Onset	TextDiagnosis Methods	TextAvailable Treatments	TextOrphan Drug Designation	TextICD-10 Code	NumberOMIM Number	TextAffected System(s)	TextDisease Severity	TextLife Expectancy Impact
01	1	Prematurity / Preterm Birth	Neonatal/Newborn	~10% of live births in US (~1 in 10); extremely preterm <28 wks ~0.7%	Acquired/Multifactorial	N/A	N/A	Birth before 37 completed weeks gestation; respiratory distress, hypothermia, feeding difficulty, apnea of prematurity, immature organ systems	Prenatal/At birth	Gestational age assessment (LMP, early US, Ballard score), birth weight, clinical exam	Antenatal corticosteroids (betamethasone), magnesium sulfate for neuroprotection, NICU thermoregulation, surfactant, respiratory support, parenteral nutrition	No	P07.30	N/A	Multisystem (respiratory, CNS, GI, immune)	Variable	Variable — extremely preterm have significant mortality and morbidity risk
02	2	Respiratory Distress Syndrome of Newborn	Neonatal/Newborn	~24,000 US cases/year; ~50% of infants 26-28 wks, >90% <28 wks	Acquired/Multifactorial	SFTPB, SFTPC, ABCA3 (rare hereditary forms)	2p11.2 (SFTPB); 8p21.3 (SFTPC); 16p13.3 (ABCA3)	Tachypnea, grunting, nasal flaring, intercostal/subcostal retractions, cyanosis, ground-glass CXR with air bronchograms	Birth to first hours of life	Clinical presentation, chest radiograph (reticulogranular pattern), blood gases, lecithin/sphingomyelin ratio	Exogenous surfactant (poractant alfa, beractant, calfactant), CPAP, mechanical ventilation, oxygen, antenatal steroids	No	P22.0	267450	Respiratory	Severe	Significant if untreated; excellent with modern surfactant therapy
03	3	Transient Tachypnea of the Newborn	Neonatal/Newborn	~5.7 per 1000 term births; higher after elective cesarean	Acquired/Multifactorial	N/A	N/A	Tachypnea >60/min within 2 hours of birth, mild retractions, nasal flaring, mild cyanosis, self-limited course	First hours of life	Clinical diagnosis of exclusion, CXR (perihilar streaking, fluid in fissures, hyperinflation)	Supportive care, supplemental oxygen, CPAP if needed, monitoring; usually resolves in 24-72 hours	No	P22.1	N/A	Respiratory	Mild	None — self-limited, excellent prognosis
04	4	Meconium Aspiration Syndrome	Neonatal/Newborn	~2-9% of meconium-stained amniotic fluid deliveries; declining incidence	Acquired/Multifactorial	N/A	N/A	Respiratory distress, cyanosis, barrel chest, rales/rhonchi, meconium-stained skin/nails, persistent pulmonary hypertension	Birth/First hours of life	Clinical history of meconium-stained fluid, CXR (patchy infiltrates, hyperinflation), hypoxemia, echocardiogram	Endotracheal suctioning if non-vigorous, oxygen, mechanical ventilation, surfactant lavage, iNO, ECMO in severe cases	No	P24.01	N/A	Respiratory	Severe	Variable — mortality 4-12% in severe disease
05	5	Neonatal Hypoxic-Ischemic Encephalopathy (severe)	Neonatal/Newborn	~1-8 per 1000 live births in developed countries	Acquired/Multifactorial	N/A	N/A	Severe: coma, flaccid tone, absent primitive reflexes, prolonged seizures, decerebrate posturing, multiorgan dysfunction	At birth	Apgar scores, cord gas (pH <7.0, BE <-12), Sarnat staging, EEG, brain MRI, aEEG	Therapeutic hypothermia (33.5°C for 72h) within 6h of birth, seizure control, supportive care, ventilation	No	P91.63	N/A	Central nervous system (multisystem)	Critical	Severe — high mortality and severe neurodevelopmental disability in survivors

Pediatric Disorders

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