Sample rows from Mental Disorders. Field types are labelled in each column heading.
#	TextID	TextDisease Name	TextCategory	TextPrevalence	TextInheritance Pattern	TextAffected Gene(s)	LocationChromosome Location	TextKey Symptoms	TextTypical Age of Onset	TextDiagnosis Methods	TextAvailable Treatments	TextOrphan Drug Designation	TextICD-10 Code	NumberOMIM Number	TextAffected System	TextDisease Severity	TextLife Expectancy Impact
01	1	Mild Intellectual Developmental Disorder	Neurodevelopmental	~0.5-0.8% general population (DSM-5-TR); ~85% of all intellectual disability cases	Variable (polygenic / de novo / environmental)	Polygenic; many genes including CNVs	Multiple loci	IQ ~50-69, conceptual learning delays, impaired social judgment, reading/writing below grade level, slower academic progress, some adaptive skill limitations, can live independently with support	Childhood (before age 18)	DSM-5-TR: deficits in intellectual + adaptive functioning; Wechsler/Stanford-Binet IQ; Vineland-3, ABAS-3; onset in developmental period	Special education, behavioral therapy, vocational training, family support; no disease-modifying drug	No	F70	N/A	CNS / Cognitive / Adaptive	Mild	Slightly reduced
02	2	Moderate Intellectual Developmental Disorder	Neurodevelopmental	~0.1-0.3% population (~10% of ID cases)	Variable (genetic syndromes common: Down, Fragile X, FAS)	Multiple (trisomy 21, FMR1, others)	Multiple loci (often 21q, Xq27.3)	IQ ~35-49, marked language delay, basic self-care with support, supervised employment feasible, academic ceiling ~2nd grade, needs ongoing social support	Infancy/early childhood	DSM-5-TR adaptive + IQ criteria; karyotype, chromosomal microarray, FMR1 testing, metabolic screen, brain MRI	Early intervention, speech/OT/PT, behavioral therapy, supported living, manage comorbidities	No	F71	N/A	CNS / Cognitive / Adaptive	Moderate	Moderately reduced
03	3	Severe Intellectual Developmental Disorder	Neurodevelopmental	~0.03-0.04% population (~3.5% of ID)	Variable (usually identifiable genetic/metabolic cause)	Multiple	Multiple loci	IQ ~20-34, minimal speech, requires assistance with all ADLs, significant motor impairment, frequent seizures, limited academic skills, fully dependent	Infancy	DSM-5-TR criteria; comprehensive genetic panel, metabolic workup, EEG, MRI brain	Intensive support, AAC devices, PT/OT, seizure management, feeding support	No	F72	N/A	CNS / Cognitive	Severe	Moderately to severely reduced
04	4	Profound Intellectual Developmental Disorder	Neurodevelopmental	~0.01-0.05% population (~1-2% of ID)	Usually syndromic/genetic	Often structural brain anomalies + single-gene disorders	Multiple loci	IQ <20, conceptual skills limited to physical world, minimal/no verbal communication, fully dependent, severe seizures, feeding difficulty, sensory and motor impairments	Infancy	DSM-5-TR criteria; whole exome sequencing, neuroimaging, metabolic, EEG	24-hour care, seizure management, G-tube feeding, orthopedic care, palliative approach	Sometimes	F73	N/A	CNS / Cognitive / Motor	Severe	Severely reduced
05	5	Global Developmental Delay	Neurodevelopmental	~1-3% of children under age 5	Variable	Varies (genetic, acquired, idiopathic)	Multiple loci	Failure to meet multiple developmental milestones (motor, speech, cognitive, social), hypotonia often present, delayed walking/talking, used when child too young for reliable IQ testing	Before age 5	DSM-5-TR: delays in >=2 domains in child too young for IQ testing; chromosomal microarray, FMR1, metabolic, MRI	Early intervention, PT/OT/speech therapy, family support, address etiology	No	F88	N/A	CNS / Neurodevelopmental	Variable	Variable

Mental Disorders

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